Rapid and precise diagnosis of the causative virus SARS-CoV-2 under COVID-19 pandemic conditions is essential for the control of infection in both asymptomatic viral carriers and individuals with signs of the disease. Diagnostic tests allow identifi cation of contact persons, timely starting of treatment, possibilities for assessing progress of disease. They are the basis for important decisions aiming minimizing of the virus spread in the society, especially when effective therapy and appropriate vaccines are lacking. In this review, we summarize the two main groups of diagnostic tests – molecular and serologic ones – a subject of permanent evolving and improvement. Special attention is paid to different factors during performance of the tests as types of samples, intended use of every test and its correct interpretation.