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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">97</journal-id>
      <journal-id journal-id-type="index">urn:lsid:arphahub.com:pub:B5033382-9D21-53CE-B630-B4E3A1146D51</journal-id>
      <journal-title-group>
        <journal-title xml:lang="en">Bulgarian Cardiology</journal-title>
        <abbrev-journal-title xml:lang="en">Bulgarian Cardiology</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">1310-7488</issn>
      <issn pub-type="epub">2683-1015</issn>
      <publisher>
        <publisher-name>Bulgarian Society of Cardiology</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.3897/bgcardio.26.e52847</article-id>
      <article-id pub-id-type="publisher-id">52847</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review Article</subject>
        </subj-group>
        <subj-group subj-group-type="scientific_subject">
          <subject>Heart Failure (сърдечна недостатъчност)</subject>
          <subject>Ischemic Heart Disease (исхемична болест на сърцето)</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>COVID-19:  when the world falls to its knees because of a virus</article-title>
      </title-group>
      <contrib-group content-type="authors">
        <contrib contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Mladenova</surname>
            <given-names>Yoana</given-names>
          </name>
          <email xlink:type="simple">yoanamladenova89@gmail.com</email>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
        <contrib contrib-type="author" corresp="no">
          <name name-style="western">
            <surname>Gospodinov</surname>
            <given-names>Konstantin</given-names>
          </name>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
        <contrib contrib-type="author" corresp="no">
          <name name-style="western">
            <surname>Stancheva</surname>
            <given-names>Nadya</given-names>
          </name>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
        <contrib contrib-type="author" corresp="no">
          <name name-style="western">
            <surname>Tisheva-Gospodinova</surname>
            <given-names>Snezhanka</given-names>
          </name>
          <uri content-type="orcid">https://orcid.org/0000-0003-3787-5620</uri>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
      </contrib-group>
      <aff id="A1">
        <label>1</label>
        <addr-line content-type="verbatim">First Clinic of Cardiology. UMHAT “ Dr. Georgi Stranski”, MU - Pleven, Pleven, Bulgaria</addr-line>
        <institution>First Clinic of Cardiology. UMHAT “ Dr. Georgi Stranski”, MU - Pleven</institution>
        <addr-line content-type="city">Pleven</addr-line>
        <country>Bulgaria</country>
      </aff>
      <author-notes>
        <fn fn-type="corresp">
          <p>Corresponding author: Yoana Mladenova (<email xlink:type="simple">yoanamladenova89@gmail.com</email>).</p>
        </fn>
        <fn fn-type="edited-by">
          <p>Academic editor: Ivan Gruev</p>
        </fn>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2020</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>06</day>
        <month>07</month>
        <year>2020</year>
      </pub-date>
      <volume>26</volume>
      <issue>2</issue>
      <fpage>27</fpage>
      <lpage>38</lpage>
      <uri content-type="arpha" xlink:href="http://openbiodiv.net/35A46457-EC1C-5E77-A873-DC4DA426C259">35A46457-EC1C-5E77-A873-DC4DA426C259</uri>
      <uri content-type="zenodo_dep_id" xlink:href="https://zenodo.org/record/3943233">3943233</uri>
      <history>
        <date date-type="received">
          <day>02</day>
          <month>04</month>
          <year>2020</year>
        </date>
        <date date-type="accepted">
          <day>26</day>
          <month>05</month>
          <year>2020</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Yoana Mladenova, Konstantin Gospodinov, Nadya Stancheva, Snezhanka Tisheva-Gospodinova</copyright-statement>
        <license license-type="creative-commons-attribution" xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
          <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
        </license>
      </permissions>
      <abstract>
        <label>Abstract</label>
        <p>COVID-19 is caused by SARS-CoV-2. In March 2020, the WHO declared a pandemic of COVID-19. The virus attacks human angiotensin-converting enzyme 2 receptors (ACE2), which are found in the lungs, vessels, heart, kidneys. This is the cause of the formation of multiple organ dysfunction in severe cases. These ones  are observed in patients with accompanying CVD, hypertension, DM, cancer, immune deficiencies. It can lead to hundreds of damage to the cardiovascular system such as myocarditis and CH. Treatment with antiviral medications may cause additional myocardial devices, including rhythm-conduction disorders. The use of ACE inhibitors and ARBs continues according to current guidelines, based on a number of evidence from clinical trials for their use, in the absence of such harm to date in the course of the COVID-19 pandemic.</p>
      </abstract>
    </article-meta>
  </front>
</article>
