A bacterial infection of the heart’s endocardial surface causes infectious endocarditis (IE). The heart valves or an intracardiac devices are most affected. In most cases of right-sided endocarditis, the tricuspid valve is involved. Using drugs like cocaine, heroin, or any number of others can cause this disorder. Infective endocarditis can develop if methadone is not administered in accordance with the Methadone program, despite the cessation of drug use. In drug users, Staphylococcus aureus is the most common cause of right-sided infective endocarditis with pulmonary embolism and persistent bacteraemia. Cutaneous vasculitis, particularly leukocytoclastic vasculitis, is a rare manifestation of IE.