Patients with recurrent vasovagal syncope with cardioinhibitory or mixed mechanism, or with symptomatic functional sinus bradycardia or AV block can be treated with cardioneuroablation. Material and methods: A case series of 5 patients is presented – four with recurrent syncope and/or symptomatic sinus bradycardia, and one with paroxysmal atrial fi brillation and recurrent syncope. After a confi rmation of the syncope mechanism with tilt table test, and after positive atropine test, radiofrequency catheter cardioneuroablation was performed (this was adjunctive procedure for the patient with atrial fi brillation who received pulmonary vein isolation). During short-term follow-up none of the patients had syncopal recurrence. Conclusion: Catheter neuromodulation provided very good short-term results and lack of serious complications in this fi rst case series in Bulgaria.